[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.6.3″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Shingles are the reactivation<\/em> of the chickenpox virus but according to the CDC, nobody really knows what triggers the reactivation: \u201cScientists aren\u2019t sure why the virus can reactivate years later, causing shingles.\u201d[i]<\/a><\/p>\n There are, however, a surprising number of diseases, conditions, and pharmaceuticals that appear to increase the risk for shingles, from aging to psoriasis and chemotherapy. Most of them seem to have a common denominator \u2013 a weakness in the immune system.<\/p>\n Advanced age increases the risk of developing shingles and by the time you get to age 85, the chance of getting it is fifty-fifty.[ii]<\/a> Additionally, older people tend to suffer more complications. This might be from immunosenescence \u2013 the gradual decline in immunity associated with increasing age.<\/p>\n Diseases that compromise the immune system, like cancer, AIDS, diabetes, leukemia, chronic kidney disease, inflammatory bowel disease (IBD), multiple sclerosis, \u00a0and lymphoma increase the risk of shingles, as do immunosuppressive medications for things like rheumatoid arthritis and bone marrow and organ transplants. Drugs like corticosteroids, chemotherapy, and transplant-related immunosuppressive medications are also associated with shingles.<\/p>\n In a recent prospective study, researchers found that herpes zoster was significantly associated with being female. [iii]<\/a> They examined the data on more than 27 million individuals and out of almost a million diagnosed shingles cases, 62% were women.<\/p>\n Autoimmune diseases also affect more women than men. All of this could be attributed to hormonal fluctuations, especially during pregnancy and menopause, both of which can trigger immune-related diseases such as diabetes. Researchers have noticed an association between both pregnancy and menopause and autoimmune diseases.<\/p>\n The efficient functioning of the immune system is heavily dependent on optimal nutrition. Two of the most important nutrients for immune function are vitamins C and D. Vitamin C deficiency means weakened immunity and therefore a higher susceptibility to infections, including viral one like herpes zoster.<\/p>\n Almost every tissue type in the body has receptors for vitamin D and it has a profound effect on the immune system. \u00a0\u201cConsidering the importance of vitamin D in host immunity, we hypothesize that vitamin D acts as an effect-modifier for the entire herpes zoster spectrum with regard to disease susceptibility, manifestation, the efficacy of pharmacologic management, and emergent complications during treatment.\u201d [iv]<\/a><\/p>\n \u201cThis reactivation occurs when immunity to VZV declines because of aging or immunosuppression.\u201d[v]<\/a><\/p>\n Shingles occur when cell-mediated immunity to chickenpox wanes and drops below a certain level. With age, the memory of immune cells can decrease along with the decline in mental memory.<\/p>\n Ironically, the chickenpox vaccine has been linked to an increase in shingles. Adults who previously contracted chickenpox in their youth can get a natural \u201cbooster\u201d shot to their immunity to varicella-zoster by contact with children with chickenpox. The vaccine has changed all of this.<\/p>\n \u201cMass use of the chickenpox vaccine by children has eliminated the opportunity for natural asymptomatic boosting of immunity in adults and left adults vulnerable to shingles later in life.\u201d[vi]<\/a><\/p>\n Depression seems to increase the risk of shingles. A population-based case-control study of subjects in Denmark and the United Kingdom concluded: \u201cmood disorders were associated with an increased risk of zoster.\u201d<\/p>\n The authors of the study write:\u00a0\u201cZoster is caused by reactivation of the varicella-zoster virus (VZV) from sensory ganglia when cell-mediated immunity (CMI) wanes below a critical level. Mood disorders, such as depression and anxiety, have been associated with impaired CMI. In particular, it has been demonstrated that VZV-specific CMI is reduced in major depression and is negatively associated with severity.\u201d[vii]<\/a><\/p>\n [i]<\/a> https:\/\/www.cdc.gov\/shingles\/about\/overview.html<\/p>\n [ii]<\/a> https:\/\/www.pennlive.com\/life\/2012\/06\/for_seniors_85_and_older_shing.html<\/p>\n [iii]<\/a> https:\/\/www.infectiousdiseaseadvisor.com\/home\/topics\/sexually-transmitted-diseases\/incidence-of-herpes-zoster-higher-among-women-and-older-adults\/<\/p>\n [iv]<\/a> https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26163058<\/p>\n [v]<\/a> https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2664599\/<\/p>\n [vi]<\/a> https:\/\/www.nvic.org\/Vaccines-and-Diseases\/Chickenpox.aspx<\/a><\/p>\n [vii]<\/a> https:\/\/academic.oup.com\/aje\/article\/187\/5\/1019\/4557910<\/a><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Shingles are the reactivation of the chickenpox virus but according to the CDC, nobody really knows what triggers the reactivation: \u201cScientists aren\u2019t sure why the virus can reactivate years later, causing shingles.\u201d[i] There are, however, a surprising number of diseases, conditions, and pharmaceuticals that appear to increase the risk for shingles, from aging to psoriasis […]<\/p>\n","protected":false},"author":2,"featured_media":416,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" Shingles is the reactivation<\/em> of the chicken pox virus but according to the CDC, nobody really knows what triggers the reactivation: \u201cScientists aren\u2019t sure why the virus can reactivate years later, causing shingles.\u201d[i]<\/a><\/p> There are, however, a surprising number of diseases, conditions, and pharmaceuticals that appear to increase the risk for shingles, from aging to psoriasis and chemotherapy. Most of them seem to have a common denominator \u2013 a weakness in the immune system.<\/p> Advanced age increases the risk of developing shingles and by the time you get to age 85, the chance of getting it is fifty-fifty.[ii]<\/a> Additionally, older people tend to suffer more complications. This might be from immunosenescence \u2013 the gradual decline in immunity associated with increasing age.<\/p> Diseases that compromise the immune system, like cancer, AIDS, diabetes, leukemia, chronic kidney disease, inflammatory bowel disease (IBD), multiple sclerosis, \u00a0and lymphoma increase the risk of shingles, as do immunosuppressive medications for things like rheumatoid arthritis and bone marrow and organ transplants. Drugs like corticosteroids, chemotherapy, and transplant-related immunosuppressive medications are also associated with shingles.<\/p> In a recent prospective study, researchers found that herpes zoster was significantly associated with being female. [iii]<\/a> They examined the data on more than 27 million individuals and out of almost a million diagnosed shingles cases, 62% were women.<\/p> Autoimmune diseases also affect more women than men. All of this could be attributed to hormonal fluctuations, especially during pregnancy and menopause, both of which can trigger immune-related diseases such as diabetes. Researchers have noticed an association between both pregnancy and menopause and autoimmune diseases.<\/p> The efficient functioning of the immune system is heavily dependent on optimal nutrition. Two of the most important nutrients for immune function are vitamins C and D. Vitamin C deficiency means weakened immunity and therefore a higher susceptibility to infections, including viral one like herpes zoster.<\/p> Almost every tissue type in the body has receptors for vitamin D and it has a profound effect on the immune system. \u00a0\u201cConsidering the importance of vitamin D in host immunity, we hypothesize that vitamin D acts as an effect-modifier for the entire herpes zoster spectrum with regard to disease susceptibility, manifestation, efficacy of pharmacologic management, and emergent complications during treatment.\u201d [iv]<\/a><\/p> \u201cThis reactivation occurs when immunity to VZV declines because of aging or immunosuppression.\u201d[v]<\/a><\/p> Shingles occurs when cell-mediated immunity to chicken pox wanes and drops below a certain level. With age, the memory of immune cells can decrease along with the decline in mental memory.<\/p> Ironically, the chicken pox vaccine has been linked to an increase in shingles. Adults who previously contracted chicken pox in their youth can get a natural \u201cbooster\u201d shot to their immunity to varicella zoster by contact with children with chicken pox. The vaccine has changed all of this.<\/p> \u201cMass use of the chickenpox vaccine by children has eliminated the opportunity for natural asymptomatic boosting of immunity in adults and left adults vulnerable to shingles later in life.\u201d[vi]<\/a><\/p> Depression seems to increase the risk for shingles. A population-based case-control study of subjects in Denmark and the United Kingdom concluded: \u201cmood disorders were associated with an increased risk of zoster.\u201d<\/p> The authors of the study write:\u00a0\u201cZoster is caused by reactivation of the varicella-zoster virus (VZV) from sensory ganglia when cell-mediated immunity (CMI) wanes below a critical level. Mood disorders, such as depression and anxiety, have been associated with impaired CMI. In particular, it has been demonstrated that VZV-specific CMI is reduced in major depression and is negatively associated with severity.\u201d[vii]<\/a><\/p> [i]<\/a> https:\/\/www.cdc.gov\/shingles\/about\/overview.html<\/p> [ii]<\/a> https:\/\/www.pennlive.com\/life\/2012\/06\/for_seniors_85_and_older_shing.html<\/p> [iii]<\/a> https:\/\/www.infectiousdiseaseadvisor.com\/home\/topics\/sexually-transmitted-diseases\/incidence-of-herpes-zoster-higher-among-women-and-older-adults\/<\/p> [iv]<\/a> https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26163058<\/p> [v]<\/a> https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2664599\/<\/p> [vi]<\/a> https:\/\/www.nvic.org\/Vaccines-and-Diseases\/Chickenpox.aspx<\/a><\/p> [vii]<\/a> https:\/\/academic.oup.com\/aje\/article\/187\/5\/1019\/4557910<\/a><\/p>","_et_gb_content_width":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-22","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-shinglesnews"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/solutionsforshingles.com\/shingles\/wp-content\/uploads\/2020\/06\/Risk-Factors-for-Shingles.gif","_links":{"self":[{"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/posts\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":4,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/posts\/22\/revisions"}],"predecessor-version":[{"id":424,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/posts\/22\/revisions\/424"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/media\/416"}],"wp:attachment":[{"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/media?parent=22"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/categories?post=22"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/solutionsforshingles.com\/shingles\/wp-json\/wp\/v2\/tags?post=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Common Risk Factors for Herpes Zoster<\/h2>\n
1.\u00a0\u00a0\u00a0\u00a0 Age<\/h3>\n
2.\u00a0\u00a0\u00a0\u00a0 Immunosuppression<\/h3>\n
3.\u00a0\u00a0\u00a0\u00a0 Being female<\/h3>\n
4.\u00a0\u00a0\u00a0\u00a0 Micronutrient deficiencies<\/h3>\n
5.\u00a0\u00a0\u00a0 Declining Immunity to VZN<\/h2>\n
6.\u00a0\u00a0\u00a0\u00a0 Depression<\/h3>\n
Common Risk Factors for Herpes Zoster<\/h2>
1.\u00a0\u00a0\u00a0\u00a0 Age<\/h3>
2.\u00a0\u00a0\u00a0\u00a0 Immunosuppression<\/h3>
3.\u00a0\u00a0\u00a0\u00a0 Being female<\/h3>
4.\u00a0\u00a0\u00a0\u00a0 Micronutrient deficiencies<\/h3>
5.\u00a0\u00a0\u00a0 Declining Immunity to VZN<\/h2>
6.\u00a0\u00a0\u00a0\u00a0 Depression<\/h3>